The primary outcomes of interest for the analysis were myocardial infarction, stroke, and all-cause mortality. For the purpose of analysis, pregnancy loss was categorized as 0, 1, 2, or 3 or more pregnancy losses. Investigators defined pregnancy loss as a registered spontaneous abortion, missed abortion, or blighted ovum in the National Patient Register. Investigators identified 1,120,532 male partners eligible for inclusion. Of these, 1,112,507 were considered eligible for analysis of myocardial infarction. Using national registry data, investigators identified 1,112,563 women eligible for inclusion. With this in mind, investigators designed their study as register-based cohort study of all people born between 19, residing in Denmark between 19, and with a registered partner of the opposite sex. 2 Led by Anders Pretzmann Mikkelsen, MD, PhD, of the Department of Gynaecology at Copenhagen University Hospital-Rigshospitalet, along with colleagues from this institution and others in Denmark, the current study was launched with the intent of better understanding associations of increased cardiovascular risk among women and their male partners following pregnancy loss. 1ĭespite this renewed emphasis, recent reports indicate women were receiving suboptimal cardiovascular care, with a July 2023 study out of Northwestern University Feinberg School of Medicine suggesting just 60% of at-risk women reported receiving counseling on cardiovascular health at their postpartum visit. “This nationwide cohort study found that pregnancy loss or stillbirth was significantly associated with incident myocardial infarction and stroke, but not all-cause mortality, in women,” wrote investigators. An analysis of data from more than 1.1 million women and their male partners is providing new insight into differences in risk of myocardial infarction and all-cause mortality following pregnancy loss.Ī register-based cohort study including all people born in Denmark between 19, results indicate experiencing pregnancy loss was associated with an increased risk of myocardial infarction, but not all-cause mortality, among women, with investigators noting no apparent increase in risk for either outcome among male partners.
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